The aims of the present study were to describe the normative distribution of HbA1c values and to investigate the factors associated with HbA1c values in Korean youths and young adults, using nationally representative data. Normative studies of children and adolescents, mostly conducted in the USA, showed differences in the distribution of HbA1c values based on age values tended to be higher during adolescence 5, 8, 9. However, there has been no population-based study on HbA1c reference values in Korean youths and young adults the previously published studies contain no data on the distribution of HbA1c values in the Asian paediatric population.Ĭonsidering the rapidly increasing prevalence of obesity and type 2 DM in children and adolescents, and the increasing use of HbA1c as a marker of glucose metabolism, it is important to establish normative reference values for the Korean population. Only a few population-based studies on HbA1c reference values have been performed to date 8, 9 these have demonstrated differences in the distribution of HbA1c values based on age, sex, and ethnicity. HbA1c levels in adults show age-, sex-, and ethnicity-related differences, implying the need to establish reference values according to relevant factors 5, 6, 7. Its normal range in adult populations is up to 5.7% (39 mmol/mol) 2, 3, 4. In addition, HbA1c is a useful predictor of cardiovascular disease and metabolic syndrome. Glycated haemoglobin (HbA1c) is used as a tool to diagnose diabetes mellitus (DM) and is the best indicator of glycaemic control in patients with DM 1. There were significant differences in the level of HbA1c according to age and sex. The present study provides nationally representative data on the distribution of HbA1c values in Korean youth and young adults. After controlling for confounding variables, the HbA1c values of youths and male participants were significantly higher than those of young adults and female participants. When age was grouped into 5-year intervals, HbA1c was the highest in those aged 10–14 years and the lowest in those aged 20–24 years. Male participants showed significantly higher HbA1c level than females ( P < 0.001). Percentiles of HbA1c were calculated and HbA1c values were compared according to age, sex, and associated factors. A total of 6,418 participants (male 3,140 ) aged 10–29 years were included in the analysis. Data from the Korea Health and Nutrition Examination Survey (2011–2015) were used. The present study aimed to describe the distribution of and to investigate the factors associated with glycated haemoglobin (HbA1c) values in Korean youth (10–19 years old) and young adults (20–29 years old).
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